An Assessment of InP/ZnS as Potential Anti-Cancer Therapy: Quantum Dot Treatment Increases Apoptosis in HeLa Cells

InP/ZnS quantum dots (QDs) are an emerging option in QD technologies for uses of fluorescent imaging as well targeted drug and anticancer therapies based on their customizable properties. In this study we explored effects when treated with HeLa cervical cancer cells. We employed XTT viability assays, reactive oxygen species (ROS) analysis, apoptosis analysis to better understand cytotoxicity extents at different concentrations InP/ZnS. addition, compared the transcriptome profile from QD-treated cells that untreated identify changes response QD. RT-qPCR assay was performed confirm findings mode action illustrated. Our determined both IC50 concentration 69 µg/mL MIC 167 It observed via cell decreased significantly MIC. Production superoxide, measured by ROS flow cytometry, decreased, whereas levels nitrogen radicals increased. Using apoptosis, found induced death samples shown be increased conclude decrease inducing stress levels, induction, alteration transcriptome.